Riboflavin and Hepatic Kynurenine Hydroxylase
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چکیده
منابع مشابه
Developmental and genetic studies on kynurenine hydroxylase from Drosophila melanogaster.
The level of kynurenine hydroxylase was measured throughout the development of wild type and the eye color mutants v, cn, st, ltd, cd, kar, w, ca, bri and p(P) of Drosophila melanogaster. In all cases except cn a bimodal distribution of enzyme activity during development was observed. Activity is initially detectable in second instar. A maximum is reached in early third instar. Activity decline...
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Phillips, R. S. & Kaufman, S. (1984) J. Biol. Chem. 259,2474-2479 Pogson, C. I., Carpenter, W. R., Cook, J . S., Fisher, M. J., Lomax, M. A,, Salter, M. &Stanley, J . C. (1984) Proc. Nutr. Soc. 43, 119132 Salter, M., Stanley, J. C., Fisher, M. J. & Pogson, C. I. (1984) Biochem. J . 221, 431-438 Shiman, R. & Jefferson, L. S. (1982) J. Biol. Cham. 257, 839-844 Shiman, R., Mortimore, G. E., Schwor...
متن کاملRiboflavin and Mouse Hepatic Cell Structure and Function
Mice which had been on a riboflavin-free diet for 6-8 wk were given daily intraperitoneal injections of riboflavin. The hepatic mitochondria, which in the deficient animals were greatly enlarged, were restored to normal dimensions within 3 days. Normalization of the mitochondrial population was brought about by division of the giant organelles. Dividing mitochondria were characterized by a memb...
متن کاملRiboflavin and Rat Hepatic Cell Structure and Function
Weanling rats were fed a simple riboflavin-deficient diet or the same diet supplemented with galactoflavin. Oxidative phosphorylation was studied in isolated hepatic mitochondria. Throughout the course of the experimental diets, a total of 8 weeks, there were no alterations in the respiratory control ratios or in the ADP/O ratios of the isolated mitochondria. Succinate dehydrogenase activity de...
متن کاملIanthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata.
Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC(50) value of 1.5 μM. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodeg...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)98156-1